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Antabuse ( Disulfiram) counters chronic alcoholism because it’s an alcohol antagonist. Physicians prescribe it to patients struggling with alcohol addiction. The drug antagonizes the alcohol by obstructing its metabolic process. It causes intolerable reactions such as reddening of the face, headache, nausea, and vomiting when someone consumes anything containing alcohol. Therefore, making it difficult for someone addicted to alcohol to keep drinking. So, how does this happen? Well, here is a comprehensive Antabuse guide.


The FDA approved Antabuse as a remedy for chronic alcoholism in 1951. It’s still one of the alcohol use disorder regimens to this date. Physicians often prescribe it to individuals who have gone through detoxification and wish to stop drinking. The medication doesn’t replace other forms of addiction treatment like counseling, psychotherapy, or the like. It should act as a contributory regimen.

Action in the Body

It works by interfering with alcohol metabolism in the body. It blocks acetaldehyde dehydrogenase from further processing the alcohol into acetic acid. Therefore, there will be a buildup of acetaldehyde in the blood. In turn, it may cause unpleasant effects that deter people diagnosed with chronic alcoholism from consuming more alcohol.

Typically, the indications of the reaction will appear 10-30 minutes after ingesting alcohol and can persist for a few hours. The alcohol consumed and your dosage level determine the severity of the reaction. The indications can be severe. In some cases, they can be fatal.

Here are some of the symptoms of acetaldehyde buildup.

  • Increased palpitations.

  • Flashing or redness of the skin.

  • Skin hives

  • Headaches

  • Vertigo or dizziness

  • Increased thirst or dehydration.

  • Nausea or vomiting.

  • Swelling of the face.

  • Chest pains

  • Low blood pressure

  • Difficulty breathing.

Some of these symptoms are fatal. So, stay away from any food or product that contains alcohol at all costs. Even a tiny amount of alcohol can lead to some distressing side effects.

Additionally, inform your healthcare provider of your current medications or supplements. Some of these medications may contain alcohol. Also, their interaction with Disulfiram may increase the probability of developing undesired reactions in the body.

Consumption and Dosage

It is not safe to take Disulfiram if you’ve consumed alcohol or anything with alcohol within the last 12 hours. It’s an oral mediation. You can take it alone or with food. Preferably, take it each morning or as recommended by your doctor.

Tip: You can take the medication before bedtime if you feel drowsy after taking it. Don’t skip your dose. Take it once you remember it. However, you can ignore it if the next one is approaching.

You can take 500 mg of Antabuse daily or as prescribed by your doctor as an initial dose. The starting dose shouldn’t last more than two weeks. Afterward, you can reduce your dosage level to 125mg per day. But don’t exceed 500mg. Buy 250 mg or 500 mg Antabuse tablets from our pharmacy.

Follow all your healthcare provider’s instructions when taking the medication. Do not modify the dosage or stop taking Disulfiram without informing your doctor. Also, don’t take it for an extended period. Taking it in larger dosages or for extended periods exacerbates the side effects.

Call us for a free Antabuse consultation.

Side Effects

The medication often causes undesired effects like any other medication. Here are the common side effects.

  • Drowsiness

  • Fatigue

  • Skin rash

  • Metallic taste.

These symptoms usually resolve within a few days, but if they persist or worsen, you should seek medical attention.

Serious Side Effects

Some of the severe side effects may include;

  • Confusion

  • Numbness of the hands or feet

  • Severe stomach pain

  • Depression

  • Dark urine

  • Persistent vomiting or nausea.

  • Jaundice

  • Hallucinations and seizures. Call your doctor in case of seizures or hallucinations.

  • Reduced sexual ability, particularly among male patients.

Talk to a doctor when you observe any of these side effects. The list is not exhaustive. But ensure you contact your doctor if you develop any other undesired effects when taking the medication.


Patients with a liver disease history must not take Antabuse. It may trigger liver damage in such patients. Your doctor should check the state of your liver before prescribing it.

Individuals who have been diagnosed with cardiovascular illness, hypertension, or stroke in the past should not use the drug. The conditions may worsen the severe side effects linked to Disulfiram.

Pregnant women and those who are breastfeeding should not take it. There is no assurance of its safety among pregnant or breastfeeding patients.


Antabuse should be part of an inclusive treatment program that includes counseling, psychotherapy, and support from people close to them. People taking the medication should abstain from all alcohol types and let their healthcare provider know of any medicine or supplements they are taking.

You should be under the doctor’s supervision if you plan to include Antabuse in your treatment plan. Talk to us. We have experts who can help you take the drug safely.